Intractable Migraine: A Definitive Guide

Ari Magill MD

Medically reviewed by:
Ari Magill, MD

Written by:

Intractable Migraine: A Definitive Guide

Intractable migraine (also know as status migrainosus) is a persistent or chronic, debilitating migraine without aura that significantly affects a person’s ability to function. Even when affected individuals take steps to control triggers and make deliberate lifestyle changes, it still has a major impact on their quality of life.

They typically do not respond to the most common preventative medications (medication taken daily to decrease headache frequency), such as beta-blockers, tricyclics, anticonvulsants, and calcium channel blockers.

These migraines do not usually respond to abortive medications (acute medication taken at head onset) either. Triptans, a class of prescription medications that induce vasoconstriction, and nonsteroidal anti-inflammatory drugs usually fail as well. The trials to find a treatment that actually brings relief are usually quite long and arduous. All too often relief is never found.

Also known as refractory migraines, they are often described as “relentless” and “never ending.” It is a fact of life for so many people. They go to bed with it, wake up with it, and struggle to function through the day despite the pain, nausea, vertigo, and vision disturbances that often accompany these incapacitating migraines. They can be dangerous and should be taken seriously – treated as a medical emergency.

Axon optics caught up with Dr. Jonathan Cabin of The Migraine Institute in Beverly Hills, California to get some insight into intractable migraine.

“Intractable migraine, also called Status Migrainosus, is a migraine that lasts over 72 hours and is notoriously difficult to relieve with standard migraine treatments,” says Dr. Cabin. “Normal migraines last four to 72 hours. Anything longer technically becomes an “intractable migraine”.

This intractable migraine guide is intended to provide patients with information about their condition as well as provide guidance on potential treatments that could bring much needed relief. The chronic pain of these migraines can wear on a person both physically and mentally. It is our hope that this guide will arm readers with information to alleviate their suffering.

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Signs and Symptoms of Intractable Migraine

The symptoms of intractable migraine are nearly identical to those of other types of migraines. Most patients experience these symptoms:

  • Headache, pain in the head and neck that lasts 72 hours or longer
  • Pain that is constant
  • Vision disturbances such as flashing or sparkling lights
  • Nausea
  • Vomiting
  • Tingling Sensation
  • Light sensitivity
  • Sound sensitivity
  • Speech disturbances
  • Dizziness
  • Difficulty focusing or inability to think clearly

Since this migraine lasts for three days or longer, there are other potential complications that can arise. The pain, vomiting, nausea and other symptoms can lead to other conditions including:

  • Sleep deprivation or sleep loss
  • Dehydration
  • Fatigue
  • Hypoglycemia
Intractable migraine is also called status migrainosus

Causes of Intractable Migraine

Intractable migraines are triggered by many of the same things that trigger regular migraines. While doctors don’t completely understand what causes migraines, they can agree that several key components play a significant role as migraine triggers: genetics, lifestyle, environment, and body chemistry.

They believe that when there is an upset or imbalance in any of these components, it causes changes within the brainstem which impacts how it interacts with the trigeminal nerve. The trigeminal nerve is the largest of the cranial nerves, and, as the name implies, is comprised of three nerve branches: the maxillary nerve, the ophthalmic nerve, and the mandibular nerve.

The maxillary nerve and ophthalmic nerve are sensory nerves in the face and head while the mandibular nerve does double duty managing sensory functions as well as supplying motor function like biting and chewing. The largely sensory aspect of this nerve gives it the potential to be a substantial pain pathway.

When a migraine trigger affects the trigeminal nerve, it transmits pain sensations in the face and head. The result is migraine pain.

Common migraine triggers include:

  • Genetics – a parent or family members suffers from migraines
  • Hormonal changes (women) – seems to coincide with fluctuations in estrogen which can include premenstrual, menstrual, pregnancy, and menopause
  • Stress – can be a migraine trigger as the body’s response to stress, or other stress-related issues, such as muscle tension, can create conditions that become in themselves migraine triggers
  • Foods – processed foods, salty foods, high sugar foods, ad aged cheeses
  • Food additives – monosodium glutamate (MSG), aspartame, nitrates
  • Beverages – high caffeine drinks like coffee, tea, and sodas as well as alcohol – especially wine
  • Fluctuations in wake-sleep patterns – getting too much sleep, jet lag, sleep deprivation, poor quality sleep
  • Environmental changes – weather changes, change in barometric pressure, cold weather
  • Sensory stimuli – bright lights and glare, strong smells, loud sounds, cold, heat
  • Physical influences – intense exercise or physical exertion, straining, sexual activity
  • Medications – nitroglycerin and other vasodilators, oral contraceptives, appetite suppressants (especially those with a stimulant like caffeine or other chemicals)

Age and gender also seem to often play a role in migraines. Women are three times more likely to get migraines after puberty. However, in childhood (pre-puberty), boys are affected more often than girls. Age also seems to play a part in a person’s propensity to get migraines as well as their frequency and intensity. Anyone at any age can get a migraine, but most people get their first migraine during adolescence. They tend to get progressively worse as the person ages, hitting a peak at some point during their 30s, then gradually declining in frequency and severity after that.

There is also a great deal of medical evidence that indicates an intractable migraine can be triggered or exacerbated by medication overuse. These rebound headaches occur when the patient overuses migraine medications, particularly NSAIDS like ibuprofen. High doses of migraine medications can trigger the headaches, as can taking the medication (over-the-counter or prescription) for more than ten days within a month for three consecutive months.

Diagnosing Intractable Migraine can be a long process

Diagnosing Intractable Migraine

The diagnostic criteria for intractable migraine is similar to that of regular migraines. Doctors look for the common migraine symptoms such as head pain, nausea, vomiting, and visual disturbances. However, they also look for the distinct markers for status migrainosus, such as:

  • Severity – intense or debilitating pain and/or symptoms
  • Duration – pain is unremitting and lasts 72 hours or more

The doctor will take a detailed history from the patient as well as conduct a physical examination. Tests, such as neuroimaging, may be run to rule out other health conditions or illnesses that could be causing the migraine.

Diagnosing intractable migraines is usually not a quick process. It often takes time as patient and doctor work together to identify patterns in migraine attacks. During the diagnostic process, it is vital that the patient maintain a detailed and complete headache diary. This will aid in not only finding patterns, but also in identifying triggers as well as treatments that provide relief.

All too often, patients give up because they feel that the diagnostic process is too long. They get tired, burned out, and lose hope. The only way that an effective treatment can be found, though, is if the patient persists in finding it. Keeping detailed notes and maintaining a good doctor-patient relationship will go a long way in finding a treatment that works.

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Treatment for Intractable Migraine

Intractable migraines usually do not respond, or do not respond well to most typical migraine treatments. While not all medications for migraines are effective in treating intractable migraine, there are some that seem to work. Several medication therapies have been identified that may halt intractable migraine (it should be noted that doctors advise patients who have blood vessel problems to avoid these medications):

  • Dihydroergotamine (Migranal, DHE-45) – taken as a shot or nasal spray and can also be administered intravenously in the inpatient setting as part of a protocol known as the Raskin protocol
  • Sumatriptan (Imitrex, Sumavel DosePro, Alsuma, Zecuity, and Onzetra) – available as a skin patch, nasal spray, shot, or pill

Prednisolone and corticosteroids dexamethasone (Dexpak, Dexamethasone Intensol) have been found to be effective for some patients.

Some patients find success with certain migraine preventative medications. While they may not prevent migraines entirely, they could decrease the number of attacks, especially those that turn into intractable migraines. These medications include:

  • Beta blockers (commonly used to lower blood pressure) – nadolol (Corgard), atenolol (Tenormin), propranolol (Inderal, Hemangeol, InnoPran), and metoprolol (Toprol, Lopressor)
  • Calcium channel blockers (also used for blood pressure), such as verapamil
  • Tricyclics (a type of antidepressant) – Amitriptyline
  • SNRIs (also an antidepressant) – Venlafaxine
  • Anti-seizure medications – topiramate and valproate
  • Botox

Other migraine medications may be effective, depending on the person. Some natural migraine remedies may also provide relief.

Other treatments and preventative measures include:

Neruomodulation – Several neuromodulation techniques are proving to be very effective for intractable migraine. These include single pulse transcranial magnetic stimulation (sTMS), vagus nerve stimulation (VNS), supraorbital stimulation, or external trigeminal nerve stimulation (e-TNS), and occipital nerve stimulation (ONS). These therapies have been proven to be safe and have very minimal side effects.

SphenoCath Procedure – Also called Sphenopalatine Ganglion Electrical Stimulation, this procedure involves administering Lidocaine through the nasal cavity to the Sphenopalatine Ganglion (SPG) nerve bundle. The lidocaine blocks the pain coming from the SPG nerve bundle and the migraine is eliminated.

Intravenous Propofol – This anesthetic causes sleepiness and relaxation, but has had great success as a treatment for intractable migraines. In one study, 63 of 77 participants who had intractable migraine reported that their migraines were completely gone.

Ketamine – This general anesthetic is commonly used to treat depression. However, a study published in Regional Anesthesia & Pain Medicine in November 2018, found that of the 61 participants, over 75 percent reported improvement in the intensity of their migraine after a five day inpatient treatment course.

Triptan – Daily use of this medication can help relieve some patients’ migraines.

Occipital Nerve Stimulation – This treatment involves stimulating the nerves in the back of the head, base of the skull, using electricity. It is intended to cause a tingling sensation which would mask the pain.

Chiropractic Chiropractic care for migraines is a very effective treatment for some patients. Several studies show that chiropractic treatment, including the utilization of the Gonstead method, may help relieve migraine pain and even help prevent migraine attacks, including intractable migraine.

Treatment may also include strategies to combat the symptoms as well. Medication for nausea and fluids for dehydration may also be administered IV or orally. It is important to get the body back into balance since that will help with the patient’s overall health as well as their body’s perception of the pain. In a somewhat indirect way, it can help to reduce the pain.

Precision tinted lenses have been steadily growing in popularity as many migraineurs credit them with light sensitivity and migraine relief. Often referred to as “migraine glasses” by those who wear them, the effectiveness of the glasses’ FL-41 tint is backed by studies as well as many very satisfied users.

Intractable migraine and depression often go hand in hand

Combating the Psychological Effects of Intractable Migraine

Psychiatric symptoms often accompany conditions that are debilitating and cause severe, persistent pain. Because intractable migraine disability tends to be unremitting, sometimes lasting for days, migraineurs often experience psychological impacts such as depression, anxiety, and pain catastrophizing due to the relentless pain and disruption of their daily activities and quality of life.

Dr. Cabin weighed in on this phenomenon, “In terms of other psychological side effects during and after an intractable migraine, I always recommend the practice of mindfulness meditation, along with other stress reducing activities like yoga and acupuncture.” He continues, “Migraine pain is very real, but psychological distress can trigger migraines and make the pain much, much worse. Learning to manage this stress naturally is incredibly helpful for all migraine patients.”

Some doctors prescribe antidepressants or anti-anxiety medications to combat the psychological effects of intractable migraine. However, many doctors opt for more natural approaches, including regular exercise, no skipping meals, mood boosting supplements, exposure to sunlight, and a healthy, high protein diet that includes fresh produce, whole grains, and lean meats. This has the potential to not only ward off the anxiety and depression; it could even help with the migraine pain.

Yoga, herbs, and essential oils are also favorites of migraineurs because they often help with the anxiety and depression as well as with the migraines and associated symptoms. It is a process, though, to find what works. Different people respond to different substances and treatments, so it may take a little trial and error before finding something that effectively treats the psychological side of migraines. But treating this aspect of the condition is essential on so many levels.

When to see a Doctor about Intractable Migraine

Intractable migraines have the potential to become emergency situations. The longer they continue, the more serious they can become. A headache that lasts more than 72 hours certainly warrants medical attention, whether it is contacting one’s headache specialist or going to the emergency department.

“If experiencing a migraine for over 72 hours, it is important to get emergency medical attention,” says Dr. Cabin. “The symptoms of migraines – especially nausea and vomiting – can lead to dangerous and sometimes life-threatening conditions if they persist for over 72 hours. The emergency room can provide IV medications and fluid restoration, which is critical during this time period. “

When seeking emergency treatment for an intractable migraine, the patient should bring these items with them to ensure more appropriate, focused care:

  • A statement from the diagnosing doctor or headache specialist that explains the migraine diagnosis, along with their name and contact information
  • A history of their migraine, including treatments, medication trials, what treatment has worked and what has not, as well as any typical symptoms
  • A complete list of medications with dosage information
  • Migraine diary
  • A friend for support and to act as an advocate. Ideally, this person is familiar with the patient’s migraines, symptoms, and triggers.

When a headache lasts longer than 72 hours, it is not a good idea to wait and see what happens. Research has already established links between migraines and a potentially increased risk for stroke and heart attack in women. There is also the possibility that the migraine is caused by an underlying condition.

Talking to Your Doctor about Intractable Migraines

Talking to your doctor about anything is rarely a pleasant experience, but talking about migraines can be even more difficult. There is a certain stigma attached to migraines that exists in the medical community and some doctors do not take the condition seriously. While headache specialists, neurologists, and some general practitioners do understand that migraines are more than just a headache, it isn’t always easy to find a healthcare provider who has that depth of understanding.

In any healthcare setting, be it a headache specialist, nurse practitioner, family doctor, or emergency department, these best practices for talking to your doctor about your intractable migraine can help focus care and expedite treatment:

  • Be honest about pain, frequency of migraines, lifestyle choices, behaviors, and symptoms – even if it is uncomfortable or embarrassing
  • Always keep a detailed migraine diary
  • When given medication, ask about dosage, side effects, expected outcome
  • Write down any questions beforehand so they won’t be forgotten
  • Know your family history
  • Don’t be afraid to question something you don’t understand or that concerns you

Dr. Cabin offers this advice. “As I mentioned, if a patient is experiencing an intractable migraine, emergency medical attention is required. Once this migraine has subsided, it’s important to talk to your doctor about a lifestyle and medication regimen that can help control migraine headaches, and hopefully prevent intractable migraines from happening again.”

He continues, “In addition, many patients should consider interventional treatments – like minimally-invasive trigger point surgery and Botox – which can reduce the frequency, duration and intensity of migraines, including intractable migraines, without the typically harsh side effects of medications. Although few patients know about these treatments, they have been around for many years and are incredibly effective.”

There are some very promising treatments for intractable migraine that are in the development stage

The Future of Treatment for Intractable Migraine

Researchers all over the world are working diligently to find better ways to manage migraines, especially the debilitating intractable migraines. Each year brings more advances and a better understanding of this difficult disorder. We still have a long way to go, but progress is most definitely being made. Each new study brings us closer to a cure – and if not a cure, then at least relief from migraine pain.

Dr. Cabin had this to say, “As far as cutting-edge therapy for intractable migraines, the real work is being done in prevention. On the pharmacological side, exciting new medications have become available that significantly reduce migraine intensity and frequency with the use of antibody therapies, which marks a relatively new frontier for migraine treatment. On the surgical/interventional side, the latest minimally-invasive interventions can significantly and permanently reduce the frequency, duration and intensity of migraines in over 90% of chronic migraine sufferers.  These incredible and effective prophylactic therapies will not only prevent the routine migraine, but intractable migraines, as well.”

Resources for Intractable Migraine Patients

Intractable migraines usually evolve from regular migraines, although it is not unheard-of for a patient to begin their migraine journey experiencing them. However, the same way it typically takes time for a person’s migraines to become intractable (often months or sometimes even years), it usually is a process, one that takes time, to return to normal and be migraine free. Very seldom will a new pill or treatment be the magic solution that takes it all away. Because of this long, often painful and difficult process, emotional support is absolutely vital.

Having people who understand your condition and support you is one of the most effective coping mechanisms migraineurs can have. These websites offer support and help to people who have migraines and intractable migraines.

Intractable migraines, as well as other types of migraines, are often a chronic illness. It is easy to withdraw from others as the pain makes it difficult to be social or even maintain relationships. You may not want to “burden” others with your persistent pain, or you may simply not have the energy to foster a relationship. Whatever the case, getting support in any capacity is helpful. The resources listed here will connect you to other people who have intractable migraine – just like you. They also offer valuable information and, most of all, hope for a future without migraines, without pain.


Jonathan Cabin, MD
The Migraine Institute
9401 Wilshire Boulevard Suite 650
Beverly Hills, California 90212

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8 thoughts on “Intractable Migraine: A Definitive Guide

  1. Michelle says:

    I have been dealing with a 4.5 year intractable migraine and menopause. I have tried everything and nothing works. Some of the doctors say that I am lying and there is no such thing. I haven’t been able to work in almost a year
    I cant socialize or go anywhere due to the constant pain and vertigo. The only small relief I get is from my pain medication that I get from my pain management doctor. Please give me some advice as to how to deal with this. It is very scary and I don’t know how to go about dealing with this for the rest of my life.

    • Lori Glover says:

      Thank you for sharing. Symptoms and severity absolutely vary among our customers and we never think they are lying. We have a very good return policy so that customers can try Axon Optics SpectraShield FL-41 glasses to see if they are effective for your condition. Feel free to email [email protected] or call our customer support number 779-379-2966 if you need additional product information.

    • Lori Glover says:

      SpectraShield FL-41 is a proprietary tint developed by doctors at the University of Utah Moran Eye Center. This tint blocks the portion of the visible light spectrum most associated with migraine and light sensitivity. It is available for indoor and outdoor lenses. 90% of our customers experience relief. Transitions lenses are indoor lenses that transition into outdoor lenses when exposed to direct UV rays. This transition takes about 5 minutes so they are not recommended for quick trips to the car or into stores. Most customers prefer separate indoor and outdoor frames. However, if you need constant protection and bright outdoor light is not your main sensitivity transitions may be a good consideration. Feel free to email [email protected] for more information.

  2. Angela says:

    I also have been dealing with constant migraine that occur on a daily basis. I have tried everything from anti-seizure medication, chiropractor, cervical disc replacement, deep tissue massage, acupuncture, daily regiment of high dosage muscle relaxers, diazepam, beta blocker, anti-depressants, and gabapentin. I’ve seen 5 different neurologist with 9 moths of Botox injections which I stopped due to high cost and no relief. Almost 1 year of aimovig and dilaudid 4 times a day which gives temporary relief for up to 2-3 hours per dose. I’ve also used tense units and heat to help with occipital neuralgia. I am to the point of giving up since I’ve been trying to find relief for well over 5 years. I’ve had to use intermittent FMLA due to the amount of work I miss due to incompatable ability to function and multiple doctors appts. Do you have any suggestions that could help relieve my constant pain? I even use toradol with compezine and Benadryl and even sumatriptan injections to get relief. I think I’ve attempted every possible medication offered to try and maintain keeping my job and the ability to function daily without staying in bed. Any help would be appreciated.

    • Lori Glover says:

      This has been a lot to manage! You may want to try a non-invasive, low risk management tool like our Axon Optics eyewear. All of our non-prescription frames have a lenient 30 day return policy. 90% of our customers report relief. Feel free to email [email protected] if you would like to schedule a phone consultation.

  3. SJ says:


    At the age of 52, with no previous health/lifestyle changes, I suddenly started getting migraines while working in a building with bats that gave most of my coworkers and me (all immunocompetent) disseminated histoplasmosis. The migraines ended after I left the building (where I worked for 3 years) and I haven’t had one since. My female coworker also got migraines. So perhaps others’ migraines are caused by disseminated histoplasmosis?

    Before the migraines I would typically yawn a lot and also couldn’t raise my arms at my shoulders, and while ill (among other thing) I had symptoms of multiple sclerosis, ALS, fibromyalgia, benign paroxysmal positional vertigo, etc. and I have had tinnitus, which is a red flag for disseminated histoplasmosis. Isn’t tinnitus linked to migraines?

    (Bats evolved to deal with the tinnitus and photophobia histoplasmosis causes by hunting at night using echolocation. They shed the fungus in their feces.)

    Thank you

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